Best Japanese Eye Drops

Drugstores in Japan can attest to the popularity of Japanese eye drops. These products are the most sought after in Japan, by locals and foreigners alike. This is because they are very much effective and have a range of varieties.

Japan is an advanced digital world and people have a lot of screen time. As a result, most Japanese locals depend on these drops to relieve stains, dryness, or pain, making the eye drop market very large.

Most drops produced are product-specific. There are drops specially produced for dry eyes, and some for contact lenses. With how large the market is, you might get confused about what product is best based on your budget. So we made a list of some of the best Japanese eye drops.

1. Rohto Cool 40a

best Japanese eye drops

Rohto Cool 40a is one of the best eye drop products in Japan. It is a 12ml eye drop containing four essential ingredients that nourish the eyes and help improve red tired eyes. Ingredients include vitamin E, Vitamin B6, and Sodium chondroitin sulfate.

It is quite similar to the Rohto Vita 40a. What differentiates it, is the blue packaging and the extra menthol it contains. Rohto Cool is known for its quality, affordability, and packaging. It is one of the top sellers in the eye drop market.

When applied, it gives off a cooling sensation, which stings but cools off right after it burns. When you use it for the first time, you may feel pretty uncomfortable but you will feel great in no time. It is good for dusty summers.

How to use: Apply 1 – 3 drops for each use, up to 5 times per day

2. Santen Santé Medical 12

This is another great product produced by Santé Corporation that has been in existence since 1899. Its major function is to get rid of eye fatigue, redness, and dryness. It contains a balanced amount of 12 ingredients which includes vitamin B12 and neostigmine methyl sulfate.

Are you in need of eye focus adjustment? Then this is for you. Santé Medical 12 eye drop is responsible for adjusting eye focus, moisturizing dry eyes, and supplying nutrients to the eyes. It is quite affordable as it is efficient and it gives healthier eye life to users.

How to use: Apply 1-3 drops at a time, up to 5 to 6 times daily.

3. V Rohto premium

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This product comes as an all-purpose eye drop. In fact, once you get this from the market, you can use it for dry eyes, sores, redness, itching, and to relax tired eye muscles. V Rohto premium is one of the best-selling eye products from the Rohto brand.

Once you apply this, you will experience this rejuvenating feeling. V Rohto Premium is designed to ease tiredness from excessive reading, and damages from blue light caused by gadgets like computers and phone screens.

Unlike others, V Rohto premium contains 12 ingredients that have been considered the largest in Japan. However, it is quite pricey. But if we’re being honest, it is worth every penny.

How to use: Apply 1-2 drops per use, 5-6 times a day.


4. Lion Smile 40 premium

Produced by the Lion Corporation, this eye drop is used for ridding eye fatigue and itchiness. It stabilizes tears, and rejuvenates the cornea. Lion Smile 40 premium contains 10 active ingredients and is pretty good for aged people.

If you are suffering from blurred vision, fatigue, itchiness of the eyes then this product is one you should try. It would improve your eye health and relieve you of these problems. A bottle contains 15ml volume and is quite effective for people aged 40 and above.

When you use this product, you may experience a burning sensation at first but after a few seconds, you will feel better. It is also good for tired and strained eyes.

How to use: apply 1-3 at a time, for about 3-6 times per day

5. Santé Pc

This eye drop contains maximum concentrations of vitamins B12 and B6, as well as chondroitin sulfate sodium. It helps adjust eye focus, prevents eye disease, bleary eyes, and stops itching.

Santé Pc eye drops are very popular in Japan. It looks cute and handy, comes in different designs, and can serve different purposes. What this eye drop does is rehydrate your eyes if they’re dry, reduce strain and help your eyes feel relaxed and refreshed.

When you use Santé Pc, you may experience a stinging or burning sensation at first but it cools off and leaves your eyes cleaner than ever. You should try this eye drop. It is affordable and good for people who use computers and smartphones for long periods every day.

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How to use: instill 1-3, for 5-6 times daily.

6. Rohto Digi Eye

Rohto Digi Eye as the name implies is designed for overworked eyes. If you do a lot of screen time, then the product is specifically designed for you. It helps reduce strain and nourishes the eye.

You can use it to ease dryness, irritation, and redness in your eyes. What’s more, it soothes the eyes for up to eight hours. It contains vitamins B12 responsible for the distinctive pink color that makes it look chic.

When you apply Rohto Digi Eye, it gives you a cooling sensation and in no time, you will feel relieved and relaxed.

How to use: instill 1 or 2 drops in affected eyes up to 4 times daily.

7. Santé Beauteye

Santé brand produces some of the best eye drops popular in Japan and their products precede them. Just like other Santé eye drops, Santé beauteye is quite efficient. It contains five active ingredients which include vitamin B12, taurine, and chondroitin sulfate sodium.

Santé Beauteye helps to keep your eyes moisturized, relieves eye stress, tiredness and makes your eyes healthy and sparkly. Interestingly, it helps reduce wrinkles and fine lines that appear around your eyes when you smile. Also, it enhances the look of the skin around your eyes.

If you’re looking for a product that not only keeps your eyes healthy but also helps enhance your beauty, then Santé beauteye is your best shot. It soothes tired eyes and keeps them refreshed. When you apply these beauty drops, you may experience a stinging sensation that could last up to 3 minutes but the result is worth it. Santé Beauteye will leave your eyes bright and sparkly.

How to use: Apply 1-3 drops about 5-6 times for one day

8. Santen Soft Santear

Santen Soft Santear is more like an artificial tear eye drop used to reduce dryness in the eyes. It contains properties similar to natural tears. It also helps relieve the feeling of dullness caused by a lack of tears. Santen Soft Santear is different from other eye drops.

It can be used on contact lenses (both hard and soft) and has no adverse effect. It is pretty chilled to use as it does not irritate the eyes when you’re experiencing discomfort while wearing your contact lens. It can be used for tired eyes too.

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How to use: Apply 1-3 drops per time, 5-6 times daily

9. Rohto Lycee –Rohto Lycee Contact

If you are looking for an eye drop that would keep your eyes crystal clear and bright, then Rohto Lycee is a product you should try out. It is good for healthy eyes, reduces red eyes, and gets rid of dryness.

Rohto Lycee is affordable, fancy, and has nice and colorful packaging. It is quite popular among Japanese females. It is effective for eye strain, and dry eyes.

What’s more, this product comes in a version suitable for contact lens users. It is called Rohto Lycee contact. When this is applied, it penetrates through the thick lens to moisturize your eyes. You can also use it to clean your contact lens before putting it on.

If you’re purchasing any of these products, be sure to look out for the difference.

How to use: instill 1 -2 drops in the affected area, 5-6 times daily

10. Rohto Z Pro

Rohto, Arctic Cooling Lubricant/Redness Relieving Eye Drops, 0.4-Ounce Bottles (Pack of 3) (B000S10HHW) | Amazon price tracker / tracking, Amazon price history charts, Amazon price watches, Amazon price drop alerts

This is one of the most popular eye drops in Japan and can be found in virtually every drugstore. It is used for tired and overworked eyes, helps to relieve pain and redness. What makes it even more distinct is the gold color packaging.

Rohto Z Pro has this special “free-angle nozzle” that helps you apply it from any angle. The ingredients it contains make it efficient for strain and blurry vision. When you use this product, your eyes will feel refreshed and relaxed. Try this and experience the cool, refreshing sensation it gives.

How to use: Apply 2-3 drops at a time, 5-6 times daily.


Japanese eye drops are special and popular for the wide variety of eye drops in the market as well as the effectiveness of these products. Be it dry eyes, tired eyes, eye strain, eye allergies, these products have proved efficient. Most of the eye drops listed here are highly recommended by ophthalmic experts. You can buy any of these eye drops during your visit to Japan.

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